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Slide #1. RNA Epigenetics Slide #2. RNA Epigenetics - Definition Slide #3. Epigenetics Slide #4. The Central Dogma Slide #5. The Central Dogma - 2 Slide #6. The Central Dogma - 3 Slide #7. RNA Epigenetics Slide #8. RNA Epigenetics - 2 Slide #9. Collaborators Slide #10. Transgene co-suppression in plants Slide #11. RNAi in C. elegans Slide #12. Homology-dependent gene silencing Slide #13. How does it work? What does it do? How can we use it? Slide #14. What is the mechanism of interference? Slide #15. It Dices, It Slices Slide #16. Dicer is present in organisms with an RNAi response Slide #17. Dicer is required for RNAi Slide #18. Phenotypes in the Dicer-mutant worm Slide #19. Let-7 Slide #20. microRNAs as a common mechanism for gene regulation? Slide #21. Dicer is present in organisms with an RNAi response Slide #22. Phenotype of Dicer mutant mice Slide #23. Dicer null embryos lack Oct-4 expression indicating a defect in stem cell maintenance Slide #24. RNAi as a tool for mammalian biology and therapy Slide #25. Hydrodynamic Transfection in Mice Slide #26. RNAi in mammals Slide #27. The p53 Tumor suppressor in a model of Burkitt’s-lymphoma Slide #28. M. Hemann, P. Paddison, S. Lowe Slide #29. Whole body imaging of GFP in lymphomas Slide #30. RNAi – Genetic Screens for therapeutic targets